Changes in serum-free light chain rather than intact monoclonal immunoglobulin levels predicts outcome following therapy in primary amyloidosis

Current response criteria for light-chain amyloidosis (AL) relegate FLC response to a subsidiary status relative to serum M-protein response. Given that light chains form the substrate for amyloid fibril formation, we hypothesized that changes in FLC might better predict outcome compared to changes...

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Autori principali: Kumar, Shaji K., Dispenzieri, Angela, Lacy, Martha Q., Hayman, Suzanne R., Buadi, Francis K., Zeldenrust, Steven R., Tan, Tow, Sinha, Shirshendu, Leung, Nelson, Kyle, Robert A., Rajkumar, S. Vincent, Gertz, Morie A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2011
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3773466/
https://ncbi.nlm.nih.gov/pubmed/21328431
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ajh.21948
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