A genome-wide siRNA screen identifies proteasome addiction as a vulnerability of basal-like triple-negative breast cancer cells

Basal-like triple negative breast cancers (TNBC) have poor prognosis. To identify basal-like TNBC dependencies, a genome-wide siRNA lethality screen compared two human breast epithelial cell lines transformed with the same genes - basal-like BPLER and myoepithelial HMLER. Expression of the screen’s...

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Detalhes bibliográficos
Main Authors: Petrocca, Fabio, Altschuler, Gabriel, Tan, Shen Mynn, Mendillo, Marc L., Yan, Haoheng, Jerry, D. Joseph, Kung, Andrew L., Hide, Winston, Ince, Tan A., Lieberman, Judy
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3773329/
https://ncbi.nlm.nih.gov/pubmed/23948298
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2013.07.008
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