Basal-A Triple Negative Breast Cancer Cells Selectively Rely on RNA Splicing for Survival

Prognosis of triple-negative breast cancer (TNBC) remains poor. To identify shared and selective vulnerabilities of basal-like TNBC, the most common TNBC subtype, a directed siRNA lethality screen was performed in 7 human breast cancer cell lines, focusing on 154 previously identified dependency gen...

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Vydáno v:Mol Cancer Ther
Hlavní autoři: Chan, Stefanie, Sridhar, Praveen, Kirchner, Rory, Lock, Ying Jie, Herbert, Zach, Buonamici, Silvia, Smith, Peter, Lieberman, Judy, Petrocca, Fabio
Médium: Artigo
Jazyk:Inglês
Vydáno: 2017
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5997774/
https://ncbi.nlm.nih.gov/pubmed/28878028
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-17-0461
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