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Highly sensitive single-fibril erosion assay demonstrates mechanochemical switch in native collagen fibrils

It has been established that the enzyme susceptibility of collagen, the predominant load-bearing protein in vertebrates, is altered by applied tension. However, whether tensile force increases or decreases the susceptibility to enzyme is a matter of contention. It is critical to establish a definiti...

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Autori principali: Flynn, Brendan P., Tilburey, Graham E., Ruberti, Jeffrey W.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3773243/
https://ncbi.nlm.nih.gov/pubmed/22584606
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10237-012-0399-2
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