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Mechanical Strain Stabilizes Reconstituted Collagen Fibrils against Enzymatic Degradation by Mammalian Collagenase Matrix Metalloproteinase 8 (MMP-8)

BACKGROUND: Collagen, a triple-helical, self-organizing protein, is the predominant structural protein in mammals. It is found in bone, ligament, tendon, cartilage, intervertebral disc, skin, blood vessel, and cornea. We have recently postulated that fibrillar collagens (and their complementary enzy...

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Detalhes bibliográficos
Main Authors: Flynn, Brendan P., Bhole, Amit P., Saeidi, Nima, Liles, Melody, DiMarzio, Charles A., Ruberti, Jeffrey W.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2925882/
https://ncbi.nlm.nih.gov/pubmed/20808784
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0012337
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