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Molecular mechanism of force induced stabilization of collagen against enzymatic breakdown

Collagen cleavage, facilitated by collagenases of the matrix metalloproteinase (MMP) family, is crucial for many physiological and pathological processes such as wound healing, tissue remodeling, cancer invasion and organ morphogenesis. Earlier work has shown that mechanical force alters the cleavag...

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Detalhes bibliográficos
Main Authors: Chang, Shu-Wei, Flynn, Brendan P., Ruberti, Jeffrey W., Buehler, Markus J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3309414/
https://ncbi.nlm.nih.gov/pubmed/22401852
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biomaterials.2012.02.001
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