Non‐enzymatic cross‐linking of collagen type II fibrils is tuned via osmolality switch

An important aspect in cartilage ageing is accumulation of advanced glycation end products (AGEs) after exposure to sugars. Advanced glycation results in cross‐links formation between the collagen fibrils in articular cartilage, hampering their flexibility and making cartilage more brittle. In the c...

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Bibliographic Details
Published in:J Orthop Res
Main Authors: Pouran, Behdad, Moshtagh, Parisa R., Arbabi, Vahid, Snabel, Jessica, Stoop, Reinout, Ruberti, Jeffrey, Malda, Jos, Zadpoor, Amir A., Weinans, Harrie
Format: Artigo
Language:Inglês
Published: John Wiley and Sons Inc. 2018
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Research Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6099510/
https://ncbi.nlm.nih.gov/pubmed/29334127
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jor.23857
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