Ca(2+) Influx and Tyrosine Kinases Trigger Bordetella Adenylate Cyclase Toxin (ACT) Endocytosis. Cell Physiology and Expression of the CD11b/CD18 Integrin Major Determinants of the Entry Route

Humans infected with Bordetella pertussis, the whooping cough bacterium, show evidences of impaired host defenses. This pathogenic bacterium produces a unique adenylate cyclase toxin (ACT) which enters human phagocytes and catalyzes the unregulated formation of cAMP, hampering important bactericidal...

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Autors principals: Uribe, Kepa B., Martín, César, Etxebarria, Aitor, González-Bullón, David, Gómez-Bilbao, Geraxane, Ostolaza, Helena
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2013
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3772820/
https://ncbi.nlm.nih.gov/pubmed/24058533
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0074248
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