Pharmacokinetics of four different brands of colistimethate and formed colistin in rats

OBJECTIVES: Very different labelling conventions are employed by different products of colistimethate (CMS), an inactive prodrug of colistin that is used as a last-line defence against Gram-negative ‘superbugs’. This study examined the chemical composition and pharmacokinetics in rats of four commer...

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Detalhes bibliográficos
Main Authors: He, Hui, Li, Ji-Chang, Nation, Roger L., Jacob, Jovan, Chen, Gong, Lee, Hee Ji, Tsuji, Brian T., Thompson, Philip E., Roberts, Kade, Velkov, Tony, Li, Jian
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2013
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3772743/
https://ncbi.nlm.nih.gov/pubmed/23749953
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jac/dkt207
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