Rac1 is deactivated at integrin activation sites through an IQGAP1–filamin-A–RacGAP1 pathway

Cell migration makes a fundamental contribution to both normal physiology and disease pathogenesis. Integrin engagement with extracellular ligands spatially controls, via the cyclical activation and deactivation of the small GTPase Rac1, the dynamic membrane protrusion and cytoskeletal reorganizatio...

Full description

Saved in:
Bibliographic Details
Main Authors: Jacquemet, Guillaume, Morgan, Mark R., Byron, Adam, Humphries, Jonathan D., Choi, Colin K., Chen, Christopher S., Caswell, Patrick T., Humphries, Martin J.
Format: Artigo
Language:Inglês
Published: The Company of Biologists 2013
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3772387/
https://ncbi.nlm.nih.gov/pubmed/23843620
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.121988
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items