Rac1 is deactivated at integrin activation sites through an IQGAP1–filamin-A–RacGAP1 pathway

Cell migration makes a fundamental contribution to both normal physiology and disease pathogenesis. Integrin engagement with extracellular ligands spatially controls, via the cyclical activation and deactivation of the small GTPase Rac1, the dynamic membrane protrusion and cytoskeletal reorganizatio...

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Hlavní autoři: Jacquemet, Guillaume, Morgan, Mark R., Byron, Adam, Humphries, Jonathan D., Choi, Colin K., Chen, Christopher S., Caswell, Patrick T., Humphries, Martin J.
Médium: Artigo
Jazyk:Inglês
Vydáno: The Company of Biologists 2013
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3772387/
https://ncbi.nlm.nih.gov/pubmed/23843620
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.121988
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