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Rac1 is deactivated at integrin activation sites through an IQGAP1–filamin-A–RacGAP1 pathway
Cell migration makes a fundamental contribution to both normal physiology and disease pathogenesis. Integrin engagement with extracellular ligands spatially controls, via the cyclical activation and deactivation of the small GTPase Rac1, the dynamic membrane protrusion and cytoskeletal reorganizatio...
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| 主要な著者: | , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
The Company of Biologists
2013
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3772387/ https://ncbi.nlm.nih.gov/pubmed/23843620 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.121988 |
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