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Aminoacylating Urzymes Challenge the RNA World Hypothesis
We describe experimental evidence that ancestral peptide catalysts substantially accelerated development of genetic coding. Structurally invariant 120–130-residue Urzymes (Ur = primitive plus enzyme) derived from Class I and Class II aminoacyl-tRNA synthetases (aaRSs) acylate tRNA far faster than th...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3772232/ https://ncbi.nlm.nih.gov/pubmed/23867455 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.496125 |
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