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Progress and challenges in aminoacyl-tRNA synthetase-based therapeutics
Aminoacyl-tRNA synthetases (ARSs) are universal enzymes that catalyze the attachment of amino acids to the 3′ ends of their cognate tRNAs. The resulting aminoacylated tRNAs are escorted to the ribosome where they enter protein synthesis. By specifically matching amino acids to defined anticodon sequ...
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| Publicado no: | J Biol Chem |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6462538/ https://ncbi.nlm.nih.gov/pubmed/30670594 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.REV118.002956 |
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