Vav1-phospholipase C-γ1 (Vav1-PLC-γ1) Pathway Initiated by T Cell Antigen Receptor (TCRγδ) Activation Is Required to Overcome Inhibition by Ubiquitin Ligase Cbl-b during γδT Cell Cytotoxicity

T cell antigen receptor γδ (TCRγδ) and natural killer group 2, member D (NKG2D) are two crucial receptors for γδT cell cytotoxicity. Compelling evidences suggest that γδT cell cytotoxicity is TCRγδ-dependent and can be co-stimulated by NKG2D. However, the molecular mechanism of underlying TCRγδ-depe...

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Detalhes bibliográficos
Main Authors: Yin, Shanshan, Zhang, Jianmin, Mao, Yujia, Hu, Yu, Cui, Lianxian, Kang, Ning, He, Wei
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3772191/
https://ncbi.nlm.nih.gov/pubmed/23897818
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.484600
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