Protease-Activated Receptor 1 Inhibition by SCH79797 Attenuates Left Ventricular Remodeling and Profibrotic Activities of Cardiac Fibroblasts

PURPOSE: Fibroblast activity promotes adverse left ventricular (LV) remodeling that underlies the development of ischemic cardiomyopathy. Transforming growth factor-β (TGF-β) is a potent stimulus for fibrosis, and the extracellular signal-regulated kinases(ERK) 1/2 pathway also contributes to the fi...

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Main Authors: Sonin, Dmitry L., Wakatsuki, Tetsuro, Routhu, Kasi V., Harmann, Leanne M., Petersen, Matthew, Meyer, Jennifer, Strande, Jennifer L.
Format: Artigo
Jezik:Inglês
Izdano: 2013
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3771535/
https://ncbi.nlm.nih.gov/pubmed/23598708
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1074248413485434
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