SCH79797 improves outcomes in experimental bacterial pneumonia by boosting neutrophil killing and direct antibiotic activity

OBJECTIVES: The role of protease-activated receptor 1 (PAR1) in the pathogenesis of pneumonia and sepsis is ambiguous given the existing literature. As PAR1 is classically activated by the coagulation-based protease thrombin and leads to vascular leakage, our hypothesis was that PAR1 blockade with S...

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Detalhes bibliográficos
Publicado no:J Antimicrob Chemother
Main Authors: Gupta, Naveen, Liu, Roland, Shin, Stephanie, Sinha, Ranjeet, Pogliano, Joseph, Pogliano, Kit, Griffin, John H, Nizet, Victor, Corriden, Ross
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2018
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5961356/
https://ncbi.nlm.nih.gov/pubmed/29514266
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jac/dky033
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