Factor Xa Stimulates Proinflammatory and Profibrotic Responses in Fibroblasts via Protease-Activated Receptor-2 Activation

Coagulation proteases have been suggested to play a role in the pathogenesis of tissue remodeling and fibrosis. We therefore assessed the proinflammatory and fibroproliferative effects of coagulation protease factor (F)Xa. We show that FXa elicits a signaling response in C2C12 and NIH3T3 fibroblasts...

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Detalhes bibliográficos
Main Authors: Borensztajn, Keren, Stiekema, Jurriën, Nijmeijer, Sebastiaan, Reitsma, Pieter H., Peppelenbosch, Maikel P., Spek, C. Arnold
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2008
Assuntos:
Regular Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2312363/
https://ncbi.nlm.nih.gov/pubmed/18202198
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2008.070347
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