Protease-Activated Receptor-2 Induces Myofibroblast Differentiation and Tissue Factor Up-Regulation during Bleomycin-Induced Lung Injury : Potential Role in Pulmonary Fibrosis

Idiopathic pulmonary fibrosis constitutes the most devastating form of fibrotic lung disorders and remains refractory to current therapies. The coagulation cascade is frequently activated during pulmonary fibrosis, but this observation has so far resisted a mechanistic explanation. Recent data sugge...

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Autores principales: Borensztajn, Keren, Bresser, Paul, van der Loos, Chris, Bot, Ilze, van den Blink, Bernt, den Bakker, Michael A., Daalhuisen, Joost, Groot, Angelique P., Peppelenbosch, Maikel P., von der Thüsen, Jan H., Spek, C. Arnold
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Investigative Pathology 2010
Materias:
Regular Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2993271/
https://ncbi.nlm.nih.gov/pubmed/20971733
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2010.091107
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