The epoxyketone-based proteasome inhibitors carfilzomib and orally bioavailable oprozomib have anti-resorptive and bone-anabolic activity in addition to anti-myeloma effects

Proteasome inhibitors (PIs), namely bortezomib, have become a cornerstone therapy for multiple myeloma (MM), potently reducing tumor burden and inhibiting pathologic bone destruction. In clinical trials, carfilzomib, a next generation epoxyketone-based irreversible PI, has exhibited potent anti-myel...

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Main Authors: Hurchla, MA, Garcia-Gomez, A, Hornick, MC, Ocio, EM, Li, A, Blanco, JF, Collins, L, Kirk, CJ, Piwnica-Worms, D, Vij, R, Tomasson, MH, Pandiella, A, Miguel, JF San, Garayoa, M, Weilbaecher, KN
Format: Artigo
Sprog:Inglês
Udgivet: 2012
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3771507/
https://ncbi.nlm.nih.gov/pubmed/22763387
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2012.183
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