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Is RANKL inhibition both anti-resorptive and anabolic in rheumatoid arthritis?
A small peptide, OP3-4, blocks receptor activator of NF-κB from binding to its ligand, receptor activator of NF-κB ligand (RANKL), and was reported recently to inhibit bone resorption, promote bone formation and protect cartilage in a preclinical rheumatoid arthritis model. The latter effects may re...
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| Udgivet i: | Arthritis Res Ther |
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| Main Authors: | , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
BioMed Central
2015
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4650503/ https://ncbi.nlm.nih.gov/pubmed/26577945 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13075-015-0861-5 |
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