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Specifications of a continual reassessment method design for phase I trials of combined drugs()
In studies of combinations of agents in phase I oncology trials, the dose–toxicity relationship may not be monotone for all combinations, in which case the toxicity probabilities follow a partial order. The continual reassessment method for partial orders (PO-CRM) is a design for phase I trials of c...
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| Main Authors: | , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
2013
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3771354/ https://ncbi.nlm.nih.gov/pubmed/23729323 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pst.1575 |
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