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SAMHD1-dependent retroviral control and escape in mice

SAMHD1 is a host restriction factor for human immunodeficiency virus 1 (HIV-1) in cultured human cells. SAMHD1 mutations cause autoimmune Aicardi-Goutières syndrome and are found in cancers including chronic lymphocytic leukaemia. SAMHD1 is a triphosphohydrolase that depletes the cellular pool of de...

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Detalhes bibliográficos
Main Authors: Rehwinkel, Jan, Maelfait, Jonathan, Bridgeman, Anne, Rigby, Rachel, Hayward, Bruce, Liberatore, Rachel A, Bieniasz, Paul D, Towers, Greg J, Moita, Luis F, Crow, Yanick J, Bonthron, David T, Reis e Sousa, Caetano
Formato: Artigo
Idioma:Inglês
Publicado em: European Molecular Biology Organization 2013
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3770946/
https://ncbi.nlm.nih.gov/pubmed/23872947
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2013.163
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