LKB1 Haploinsufficiency Cooperates With Kras to Promote Pancreatic Cancer Through Suppression of p21-Dependent Growth Arrest

BACKGROUND & AIMS: Patients carrying germline mutations of LKB1 have an increased risk of pancreatic cancer; however, it is unclear whether down-regulation of LKB1 is an important event in sporadic pancreatic cancer. In this study, we aimed to investigate the impact of LKB1 down-regulation for p...

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Detalhes bibliográficos
Main Authors: Morton, Jennifer P., Jamieson, Nigel B., Karim, Saadia A., Athineos, Dimitris, Ridgway, Rachel A., Nixon, Colin, McKay, Colin J., Carter, Ross, Brunton, Valerie G., Frame, Margaret C., Ashworth, Alan, Oien, Karin A., Evans, T.R. Jeffry, Sansom, Owen J.
Formato: Artigo
Idioma:Inglês
Publicado em: W.B. Saunders 2010
Assuntos:
Basic—Liver, Pancreas, and Biliary Tract
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3770904/
https://ncbi.nlm.nih.gov/pubmed/20452353
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2010.04.055
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