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Lethal NK-mediated inflammation induced by IL-12 in the absence of polymorphic and nonpolymorphic MHC class I molecules
Interleukin-12 is a potent activator and initiator of type-1 T cell development, and can be used as an adjuvant to bias for the development of vaccine-induced Th1 immune responses. During vaccination of MHC class I deficient beta-2 microglobulin knockout mice (β(2)M(−/−)) with an IL-12/αIL-4 Th1 bia...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3770801/ https://ncbi.nlm.nih.gov/pubmed/23891392 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cyto.2013.06.320 |
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