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Parallel RNA interference screens identify EGFR activation as an escape mechanism in FGFR3 mutant cancer
Activation of fibroblast growth factor receptors is a common oncogenic event. Little is known about the determinants of sensitivity to FGFR inhibition and how these may vary between different oncogenic FGFRs. Using parallel RNA interference genetic screens we demonstrate that EGFR limits sensitivity...
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| Main Authors: | , , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2013
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3770512/ https://ncbi.nlm.nih.gov/pubmed/23744832 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-12-0569 |
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