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Transplanted hypothalamic neurons restore leptin signaling and ameliorate obesity in db/db mice

Evolutionarily old and conserved homeostatic systems in the brain, including hypothalamus, are organized into nuclear structures of heterogeneous and diverse neuron populations. To investigate whether such circuits can be functionally reconstituted by synaptic integration of similarly diverse popula...

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Détails bibliographiques
Auteurs principaux: Czupryn, Artur, Zhou, Yu-Dong, Chen, Xi, McNay, David, Anderson, Matthew P., Flier, Jeffrey S., Macklis, Jeffrey D.
Format: Artigo
Langue:Inglês
Publié: 2011
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3770458/
https://ncbi.nlm.nih.gov/pubmed/22116886
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1209870
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