Mfn2 modulates the UPR and mitochondrial function via repression of PERK

Mitofusin 2 (Mfn2) is a key protein in mitochondrial fusion and it participates in the bridging of mitochondria to the endoplasmic reticulum (ER). Recent data indicate that Mfn2 ablation leads to ER stress. Here we report on the mechanisms by which Mfn2 modulates cellular responses to ER stress. Ind...

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Autors principals: Muñoz, Juan Pablo, Ivanova, Saška, Sánchez-Wandelmer, Jana, Martínez-Cristóbal, Paula, Noguera, Eduard, Sancho, Ana, Díaz-Ramos, Angels, Hernández-Alvarez, María Isabel, Sebastián, David, Mauvezin, Caroline, Palacín, Manuel, Zorzano, Antonio
Format: Artigo
Idioma:Inglês
Publicat: European Molecular Biology Organization 2013
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3770335/
https://ncbi.nlm.nih.gov/pubmed/23921556
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2013.168
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