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Prechemistry Nucleotide Selection Checkpoints in the Reaction Pathway of DNA Polymerase I and Roles of Glu710 and Tyr766

[Image: see text] The accuracy of high-fidelity DNA polymerases such as DNA polymerase I (Klenow fragment) is governed by conformational changes early in the reaction pathway that serve as fidelity checkpoints, identifying inappropriate template–nucleotide pairings. The fingers-closing transition (d...

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Autori principali: Bermek, Oya, Grindley, Nigel D. F., Joyce, Catherine M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Chemical Society 2013
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3770053/
https://ncbi.nlm.nih.gov/pubmed/23937394
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi400837k
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