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Prechemistry Nucleotide Selection Checkpoints in the Reaction Pathway of DNA Polymerase I and Roles of Glu710 and Tyr766
[Image: see text] The accuracy of high-fidelity DNA polymerases such as DNA polymerase I (Klenow fragment) is governed by conformational changes early in the reaction pathway that serve as fidelity checkpoints, identifying inappropriate template–nucleotide pairings. The fingers-closing transition (d...
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| Auteurs principaux: | , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
American Chemical
Society
2013
|
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3770053/ https://ncbi.nlm.nih.gov/pubmed/23937394 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi400837k |
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