ATF3 Protects against LPS-Induced Inflammation in Mice via Inhibiting HMGB1 Expression

Lipopolysaccharide (LPS) triggers innate immunity mainly via TLR4 signaling. ATF3 is a negative regulator of TLR4 signaling. HMGB1 plays a critical role in the final step of sepsis. However, the mechanisms of ATF3 and the role of HMGB1 in regulating innate immunity-induced sepsis are incompletely un...

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Detalhes bibliográficos
Main Authors: Lai, Pei-Fang, Cheng, Ching-Feng, Lin, Heng, Tseng, Tzu-Ling, Chen, Hsi-Hsien, Chen, Sung-Ho
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi Publishing Corporation 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3770047/
https://ncbi.nlm.nih.gov/pubmed/24062788
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2013/716481
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