MicroRNA-494 Reduces ATF3 Expression and Promotes AKI

MicroRNA-494 mediates apoptosis and necrosis in several types of cells, but its renal target and potential role in AKI are unknown. Here, we found that microRNA-494 binds to the 3′UTR of activating transcription factor 3 (ATF3) and decreases its transcription. In mice, overexpression of microRNA-494...

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Autori principali: Lan, Yi-Fan, Chen, Hsi-Hsien, Lai, Pei-Fang, Cheng, Ching-Feng, Huang, Yen-Ta, Lee, Yi-Chao, Chen, Tzen-Wen, Lin, Heng
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Nephrology 2012
Soggetti:
Basic Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3507368/
https://ncbi.nlm.nih.gov/pubmed/23160513
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2012050438
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