SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways

Protein function is regulated by diverse posttranslational modifications. The mitochondrial sirtuin SIRT5 removes malonyl and succinyl moieties from target lysines. The spectrum of protein substrates subject to these modifications is unknown. We report systematic profiling of the mammalian succinylo...

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Detalhes bibliográficos
Main Authors: Park, Jeongsoon, Chen, Yue, Tishkoff, Daniel X., Peng, Chao, Tan, Minjia, Dai, Lunzhai, Xie, Zhongyu, Zhang, Yi, Zwaans, Bernadette M.M., Skinner, Mary E., Lombard, David B., Zhao, Yingming
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3769971/
https://ncbi.nlm.nih.gov/pubmed/23806337
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2013.06.001
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