SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways

Protein function is regulated by diverse posttranslational modifications. The mitochondrial sirtuin SIRT5 removes malonyl and succinyl moieties from target lysines. The spectrum of protein substrates subject to these modifications is unknown. We report systematic profiling of the mammalian succinylo...

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Autori principali: Park, Jeongsoon, Chen, Yue, Tishkoff, Daniel X., Peng, Chao, Tan, Minjia, Dai, Lunzhai, Xie, Zhongyu, Zhang, Yi, Zwaans, Bernadette M.M., Skinner, Mary E., Lombard, David B., Zhao, Yingming
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2013
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3769971/
https://ncbi.nlm.nih.gov/pubmed/23806337
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2013.06.001
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