A SNAIL1-SMAD3/4 transcriptional repressor complex promotes TGF-β mediated epithelial-mesenchymal transition

Epithelial-mesenchymal transitions (EMT) are essential for organogenesis and triggered in carcinoma progression into an invasive state(1). Transforming growth factor-β (TGF-β) cooperates with signalling pathways, such as Ras and Wnt, to induce EMT(2-5), but the molecular mechanisms are not clear. He...

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Main Authors: Vincent, Theresa, Neve, Etienne P. A., Johnson, Jill R., Kukalev, Alexander, Rojo, Federico, Albanell, Joan, Pietras, Kristian, Virtanen, Ismo, Philipson, Lennart, Leopold, Philip L., Crystal, Ronald G., de Herreros, Antonio Garcia, Moustakas, Aristidis, Pettersson, Ralf F., Fuxe, Jonas
Format: Artigo
Sprog:Inglês
Udgivet: 2009
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3769970/
https://ncbi.nlm.nih.gov/pubmed/19597490
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb1905
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