A SNAIL1-SMAD3/4 transcriptional repressor complex promotes TGF-β mediated epithelial-mesenchymal transition

Epithelial-mesenchymal transitions (EMT) are essential for organogenesis and triggered in carcinoma progression into an invasive state(1). Transforming growth factor-β (TGF-β) cooperates with signalling pathways, such as Ras and Wnt, to induce EMT(2-5), but the molecular mechanisms are not clear. He...

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Detalhes bibliográficos
Main Authors: Vincent, Theresa, Neve, Etienne P. A., Johnson, Jill R., Kukalev, Alexander, Rojo, Federico, Albanell, Joan, Pietras, Kristian, Virtanen, Ismo, Philipson, Lennart, Leopold, Philip L., Crystal, Ronald G., de Herreros, Antonio Garcia, Moustakas, Aristidis, Pettersson, Ralf F., Fuxe, Jonas
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3769970/
https://ncbi.nlm.nih.gov/pubmed/19597490
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb1905
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