HMGA2 and Smads Co-regulate SNAIL1 Expression during Induction of Epithelial-to-Mesenchymal Transition

Epithelial-mesenchymal transition (EMT) is important during embryonic cell layer movement and tumor cell invasiveness. EMT converts adherent epithelial cells to motile mesenchymal cells, favoring metastasis in the context of cancer progression. Transforming growth factor-β (TGF-β) triggers EMT via i...

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Autores principales: Thuault, Sylvie, Tan, E-Jean, Peinado, Hector, Cano, Amparo, Heldin, Carl-Henrik, Moustakas, Aristidis
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2008
Materias:
Molecular Basis of Cell and Developmental Biology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2662269/
https://ncbi.nlm.nih.gov/pubmed/18832382
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M802016200
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