The high mobility group A2 protein epigenetically silences the Cdh1 gene during epithelial-to-mesenchymal transition

The loss of the tumour suppressor E-cadherin (Cdh1) is a key event during tumourigenesis and epithelial–mesenchymal transition (EMT). Transforming growth factor-β (TGFβ) triggers EMT by inducing the expression of non-histone chromatin protein High Mobility Group A2 (HMGA2). We have previously shown...

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Vydáno v:Nucleic Acids Res
Hlavní autoři: Tan, E-Jean, Kahata, Kaoru, Idås, Oskar, Thuault, Sylvie, Heldin, Carl-Henrik, Moustakas, Aristidis
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2015
Témata:
Gene regulation, Chromatin and Epigenetics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4288184/
https://ncbi.nlm.nih.gov/pubmed/25492890
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gku1293
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