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The Making of a Slicer: Activation of Human Argonaute-1

Argonautes are the central protein component in small RNA silencing pathways. Of the four human Argonautes (hAgo1–4) only hAgo2 is an active slicer. We determined the structure of hAgo1 bound to endogenous copurified RNAs to 1.75 Å resolution and hAgo1 loaded with let-7 miRNA to 2.1 Å. Both structur...

詳細記述

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書誌詳細
主要な著者: Faehnle, Christopher R., Elkayam, Elad, Haase, Astrid D., Hannon, Gregory J., Joshua-Tor, Leemor
フォーマット: Artigo
言語:Inglês
出版事項: 2013
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3769929/
https://ncbi.nlm.nih.gov/pubmed/23746446
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2013.05.033
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