The Making of a Slicer: Activation of Human Argonaute-1

Argonautes are the central protein component in small RNA silencing pathways. Of the four human Argonautes (hAgo1–4) only hAgo2 is an active slicer. We determined the structure of hAgo1 bound to endogenous copurified RNAs to 1.75 Å resolution and hAgo1 loaded with let-7 miRNA to 2.1 Å. Both structur...

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Bibliografiske detaljer
Main Authors: Faehnle, Christopher R., Elkayam, Elad, Haase, Astrid D., Hannon, Gregory J., Joshua-Tor, Leemor
Format: Artigo
Sprog:Inglês
Udgivet: 2013
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3769929/
https://ncbi.nlm.nih.gov/pubmed/23746446
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2013.05.033
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