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The Making of a Slicer: Activation of Human Argonaute-1
Argonautes are the central protein component in small RNA silencing pathways. Of the four human Argonautes (hAgo1–4) only hAgo2 is an active slicer. We determined the structure of hAgo1 bound to endogenous copurified RNAs to 1.75 Å resolution and hAgo1 loaded with let-7 miRNA to 2.1 Å. Both structur...
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| 主要な著者: | , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2013
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3769929/ https://ncbi.nlm.nih.gov/pubmed/23746446 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2013.05.033 |
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