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Progesterone, compared to medroxyprogesterone acetate, to C57BL/6, but not 5α-reductase mutant, mice enhances object recognition and placement memory and is associated with higher BDNF levels in the hippocampus and cortex

Progesterone (P(4)) may influence cognition in part through actions of its 5α-reduced metabolite, allopregnanolone. Ovariectomized mice that were C57BL/6 wildtype (WT), or deficient in the 5α-reductase Type 1 enzyme (5α-reductase knockout; 5αRKO), were administered vehicle, P(4), allopregnanolone, o...

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Bibliografski detalji
Glavni autori: Frye, Cheryl A., Koonce, Carolyn J., Walf, Alicia A.
Format: Artigo
Jezik:Inglês
Izdano: 2013
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3769780/
https://ncbi.nlm.nih.gov/pubmed/23872095
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neulet.2013.07.002
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