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Progesterone, compared to medroxyprogesterone acetate, to C57BL/6, but not 5α-reductase mutant, mice enhances object recognition and placement memory and is associated with higher BDNF levels in the hippocampus and cortex

Progesterone (P(4)) may influence cognition in part through actions of its 5α-reduced metabolite, allopregnanolone. Ovariectomized mice that were C57BL/6 wildtype (WT), or deficient in the 5α-reductase Type 1 enzyme (5α-reductase knockout; 5αRKO), were administered vehicle, P(4), allopregnanolone, o...

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Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Frye, Cheryl A., Koonce, Carolyn J., Walf, Alicia A.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2013
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3769780/
https://ncbi.nlm.nih.gov/pubmed/23872095
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neulet.2013.07.002
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