Inosine Monophosphate Dehydrogenase (IMPDH) Activity as a Pharmacodynamic Biomarker of Mycophenolic Acid Effects in Pediatric Kidney Transplant Recipients

Monitoring inosine monophosphate dehydrogenase (IMPDH) activity as a biomarker of mycophenolic acid (MPA)–induced immunosuppression may serve as a novel approach in pharmacokinetics (PK)/pharmacodynamics (PD)–guided therapy. The authors prospectively studied MPA pharmacokinetics and IMPDH inhibition...

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Главные авторы: Fukuda, Tsuyoshi, Goebel, Jens, Thøgersen, Håvard, Maseck, Denise, Cox, Shareen, Logan, Barbara, Sherbotie, Joseph, Seikaly, Mouin, Vinks, Alexander A.
Формат: Artigo
Язык:Inglês
Опубликовано: 2010
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3769694/
https://ncbi.nlm.nih.gov/pubmed/20418509
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/0091270010368542
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