The Design and In Vivo Evaluation of Engineered I-OnuI-Based Enzymes for HEG Gene Drive

The homing endonuclease gene (HEG) drive system, a promising genetic approach for controlling arthropod populations, utilises engineered nucleases to spread deleterious mutations that inactivate individual genes throughout a target population. Previous work with a naturally occurring LAGLIDADG homin...

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Bibliographic Details
Main Authors: Chan, Yuk-Sang, Takeuchi, Ryo, Jarjour, Jordan, Huen, David S., Stoddard, Barry L., Russell, Steven
Format: Artigo
Language:Inglês
Published: Public Library of Science 2013
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3769382/
https://ncbi.nlm.nih.gov/pubmed/24040217
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0074254
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