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Beta Cell 5′-Shifted isomiRs Are Candidate Regulatory Hubs in Type 2 Diabetes

Next-generation deep sequencing of small RNAs has unveiled the complexity of the microRNA (miRNA) transcriptome, which is in large part due to the diversity of miRNA sequence variants (“isomiRs”). Changes to a miRNA’s seed sequence (nucleotides 2–8), including shifted start positions, can redirect t...

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Hlavní autoři: Baran-Gale, Jeanette, Fannin, Emily E., Kurtz, C. Lisa, Sethupathy, Praveen
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2013
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3767796/
https://ncbi.nlm.nih.gov/pubmed/24039891
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0073240
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