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Testing the Ability of Non-Methylamine Osmolytes Present in Kidney Cells to Counteract the Deleterious Effects of Urea on Structure, Stability and Function of Proteins

Human kidney cells are under constant urea stress due to its urine concentrating mechanism. It is believed that the deleterious effect of urea is counteracted by methylamine osmolytes (glycine betaine and glycerophosphocholine) present in kidney cells. A question arises: Do the stabilizing osmolytes...

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Bibliografiske detaljer
Main Authors: Khan, Sheeza, Bano, Zehra, Singh, Laishram R., Hassan, Md. Imtaiyaz, Islam, Asimul, Ahmad, Faizan
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2013
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3767660/
https://ncbi.nlm.nih.gov/pubmed/24039776
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0072533
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