Non-Catalytic Site HIV-1 Integrase Inhibitors Disrupt Core Maturation and Induce a Reverse Transcription Block in Target Cells

HIV-1 integrase (IN) is the target for two classes of antiretrovirals: i) the integrase strand-transfer inhibitors (INSTIs) and ii) the non-catalytic site integrase inhibitors (NCINIs). NCINIs bind at the IN dimer interface and are thought to interfere primarily with viral DNA (vDNA) integration in...

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Main Authors: Balakrishnan, Mini, Yant, Stephen R., Tsai, Luong, O’Sullivan, Christopher, Bam, Rujuta A., Tsai, Angela, Niedziela-Majka, Anita, Stray, Kirsten M., Sakowicz, Roman, Cihlar, Tomas
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2013
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3767657/
https://ncbi.nlm.nih.gov/pubmed/24040198
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0074163
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