Synergistic Apoptosis of CML Cells by Buthionine Sulfoximine and Hydroxychavicol Correlates with Activation of AIF and GSH-ROS-JNK-ERK-iNOS Pathway

BACKGROUND: Hydroxychavicol (HCH), a constituent of Piper betle leaf has been reported to exert anti-leukemic activity through induction of reactive oxygen species (ROS). The aim of the study is to optimize the oxidative stress –induced chronic myeloid leukemic (CML) cell death by combining glutathi...

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Detalhes bibliográficos
Main Authors: Chowdhury, Avik Acharya, Chaudhuri, Jaydeep, Biswas, Nabendu, Manna, Anirban, Chatterjee, Saurav, Mahato, Sanjit K., Chaudhuri, Utpal, Jaisankar, Parasuraman, Bandyopadhyay, Santu
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3767640/
https://ncbi.nlm.nih.gov/pubmed/24040019
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0073672
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