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Glucocorticoid receptor represses proinflammatory genes at distinct steps of the transcription cycle

Widespread anti-inflammatory actions of glucocorticoid hormones are mediated by the glucocorticoid receptor (GR), a ligand-dependent transcription factor of the nuclear receptor superfamily. In conjunction with its corepressor GR-interacting protein-1 (GRIP1), GR tethers to the DNA-bound activator p...

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Hlavní autoři: Gupte, Rebecca, Muse, Ginger W., Chinenov, Yurii, Adelman, Karen, Rogatsky, Inez
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2013
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3767553/
https://ncbi.nlm.nih.gov/pubmed/23950223
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1309898110
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