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Two-state dynamics of the SH3–SH2 tandem of Abl kinase and the allosteric role of the N-cap
The regulation and localization of signaling enzymes is often mediated by accessory modular domains, which frequently function in tandems. The ability of these tandems to adopt multiple conformations is as important for proper regulation as the individual domain specificity. A paradigmatic example i...
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| Huvudupphovsmän: | , , , , , |
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| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
National Academy of Sciences
2013
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| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3767523/ https://ncbi.nlm.nih.gov/pubmed/23959873 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1303966110 |
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