Polyglutamine domain flexibility mediates the proximity between flanking sequences in huntingtin

Huntington disease (HD) is a neurodegenerative disorder caused by a CAG expansion within the huntingtin gene that encodes a polymorphic glutamine tract at the amino terminus of the huntingtin protein. HD is one of nine polyglutamine expansion diseases. The clinical threshold of polyglutamine expansi...

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Bibliographic Details
Main Authors: Caron, Nicholas Stephane, Desmond, Carly Robyn, Xia, Jianrun, Truant, Ray
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2013
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3767516/
https://ncbi.nlm.nih.gov/pubmed/23898200
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1301342110
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